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Pain Cure Center
cures chronic pain permanently

Clinical Studies and Outcomes of Noxipoint Therapy 

The prevailing conclusion from over eighty clinical trials in the past two decades has been that the pain reduction effect of electrical stimulation (TENS) is not medically significant, albeit statistically significant in some trials.  We employed multiple methods and multiple trials in the study, in the context of such weak efficacy of the conventional electrical stimulation in two clinical trials.  Both trials were registered at the federal registry www.clinicaltrials.gov (NCT01578148 and NCT01844167): 

Status Study
1 Completed Noxipoint Therapy Versus Standard Physical Therapy for Chronic Pain
Condition: Neck Pain; Shoulder Pain
Interventions: Test Procedure: Noxipoint Therapy  
Control Procedure: Conventional Physical Therapy (manual, exercise, heat, TENS)
2 Completed

Noxipoint Therapy Versus Conventional Physical Therapy for Chronic Neck Pain
Conditions: Neck Pain
Interventions: Test Procedure: Noxipoint Therapy  
Control Procedure: Conventional Physical Therapy (manual, exercise, heat, TENS)

Observational Study of Noxipoint® Therapy 

January 30, 2012

Dr. Charles C. Koo, PhD

Among 29 chronic pain patients and 90 cases by body areas (e.g., shoulder pain, mid/lower back pain, leg/foot pain), there were (1) 12 neck/upper back pain (2) 13 shoulder pain and (3) 8 mid/lower back pain.  The chart below shows the pain levels after the treatment, compared to normalized pains before the treatment:   


In sum, the pain of all qualified patients in each condition has been reduced to 9%, 7% and 13% of their before-treatment pain level respectively, after an average of 1.6 sessions of Noxipoint therapy.   Nearly all patients regained their full range of motion afterward and persisted.   Data from incomplete cases (when the patient aborted the treatment prematurely) are considered failed and included in the outcome. 

The success rate of the patients in the study is 93%  (27/29).  

(a) The profile: 
1. All pain patients between 11/21/2011 and 1/11/2012 are included in this report (total = 29) with their pain levels before and after treatments non-discriminatorily.   There is no preferential filtering.  
2. Most patients had pains in multiple body areas.  (Total pain areas = 78 core cases+ 12 special cases) 
3. Nearly all patients' pains were chronic.   The control is the fail case before the Nocipoint treatment.
4. Each session is typically 1.5 hours.

(b) The organization of the report:  
1. The report summarized the chart for every patient (incl., prior diagnoses, pain levels before and after, and the range of motion): 
- Patients whose treatments were completed (or almost completed) were highlighted in GREEN
- The body areas that have gone through the treatment completely are in RED font.  Note that many patients had pains in more than one body areas (e.g., shoulder + neck/upper back pain + lower back pain). Certain patients who are still work-in-progress may have areas that have been completely treated.  
2. Several noteworthy cases which show surprisingly positive outcomes are included for your interest:  e.g., menstrual  pain, Parkinson disease, interstitial cystitis.   
3. Outcome analysis per condition are summarized at the end. 

Nearly all these patients had gone through months or years of other treatments before they came to Pain Cure Center.  

         IRB-approved Controlled Studies on Noxipoint Therapy

Noxipoint® Therapy has demonstrated general applicability to a wide range of chronic pain conditions. 
wo independent controlled clinical studies have been approved by the IRB* (Institutional Review Board), and registered at www.clinicaltrials.gov, to further validate its efficacy on three conditions (TMJ disorder, shoulder pain, and neck pain): 

Both studies compare Noxipoint Therapy with the established standard of care 
(physical therapy) and placebo.  
The first study is a patient-blind study conducted in the US.  he principal investigators are Dr. Charles Koo, PhD, and Prof. David Lewis, MD, PhD at Stanford University Medical Center.  
The 2nd study is a patient-and-accessor-blinded study conducted by the Medical School of National Taiwan University (NTU) in Taiwan.  The principal investigators include: Prof. Tyng-Guey Wang, MD, Prof.  J..Y. Tsauo, PhD and.
Dr. Charles Koo, PhD at NTU.   
* IRBs
 are formally designated to approve, monitor and review medical research involving human. They are sanctioned by Department of Health and Food and Drug Administration in the US. 

Noxipoint® Therapy

Rapidly Heals Pains and Muscular Injuries
Observation Study 2010

Dr. Charles C. Koo, PhD


Thousands of people have benefited from NoxipointTM Stimulation and rapid recovery from pain.   A control analysis was conducted on a group of randomly selected people who went through this breakthrough procedure.

Patient profiles:


(a) Chronic neck pain and back pain for various (sometimes unknown) reasons, having lasted 2-20 years. All had tried many treatment protocols (physical therapy, epidural injection, acupuncture, massage, etc.) without notable improvement.   Many were also on prescribed analgesics.  Patients' ages are between 30 and 79.   

 (b) Pain/ tingling sensation at extremities or loss of motor control due to pinched nerves, which may or may not be present all the time.  Most of them had functional deficiencies.   Ages: 35-65

 (c) Lingering pain at extremities due to sports injuries, car accidents, or sudden movements.  Many were functionally impaired for over 3 months (some multiple years).  The age group: 15-68

(a) and (b) groups often had multiple areas of pain while Group (c) often had localized pain.   Most of them experienced functional constraints of their arms, legs or the back. Many had symptoms from both tissue injury and pinched nerve. They were classified in either (a) or (b) for convenience.  Many felt depressed, some showed allodynia or hyperalgersia.   Almost all patients were all stuck with chronic pains and impaired muscular functions for months or years.  

The treatment procedure: 

The patients were given the threshold-gated “Noxipoint™ electro-stimulation procedure: Electrically stimulate certain “noxipoints” that were anatomically associated with the injured tissues/sites within narrowly controlled thresholds, such as timing, amplitude, frequency and dosing.   Each session typically lasted for 1.5 hours.  It may take one to several sessions, depending on the extensiveness of the injury.

The results (based on a study of chronic pain/ injury patients):

98% patients recovered with full range of motion and only less than 10% reports Level 1 or 2 out of 10 remaining pain.  89% of patients recovered in 1-4 sessions.   Full recovery is defined as (1) gaining full range of motion (age appropriate) and (2) persistently functioning for at least one month without recurring pains.   See results shown below:  


** People who had extensive tissue damages required multiple sessions/more time to cover all the damaged tissues/ muscle groups.  

Most patients experienced substantial or complete recovery of muscle function in the first one or two treatments.  Later sessions were typically dealing with secondary/other pains that were not in the patients’ chief complaint initially.   That is, when the primary problem was cured, the patient started to notice secondary/ other pains that was masked by the primary pain.  All additional complaints were treated in this study to have full closure.

Arm and hand pains typically involve more muscle groups and often take longer time than neck/lower back pains.  Lower extremity injuries can take shorter or longer time depending on the location of the injury/pain.

Historical-Control analysis

The chronic pain patients typically had persistent pains for months or years, many of who underwent other conventional pain treatment/physical therapy (See Figure 1).     Patients who had been on pain medications were advised to stop taking them 6-12 hours before the treatment to ensure that they wore off.  No patients with epidural injections or post-surgery pains were included in this set. 

The control in this study is the chronological pain level before the treatment, while the test is the pain level after the treatment.  The patients who received the Nocipoint™ Electro-Stimulation process experienced substantial pain relief and regained function immediately after the treatment.  The recovery persisted in follow-ups.  

After each session, patients were instructed to go easy on exercises with the newly recovered muscles for a few days or a week for seniors, to prevent new injuries before the tissue gains enough strength.  



Figure 1. Relative pain levels BEFORE and AFTER Nocipoint Stimulation

In order to have a meaningful aggregation across all patients, the pain levels are normalized at the time right before the treatment.  That is, they are defined as relative pains compared to the pain level right before the Nocipoint™ electro-stimulation treatment. Chronic pain patients typically had persistent pain for months or years, with or without conventional treatment/therapy, as described in the BEFORE scenario.  Patients who received the Nocipoint™ Electro-Stimulatio process experienced substantial pain relief and regained function immediately after the treatment.  Notice that the recovery persisted afterward.  (Note: history earlier than 3 months before the treatment were truncated in this chart.)

Placebo effect consideration:  During a session, when the points for stimulation deviate a little from the intended “nocipoints” (e.g., 10 mm) mistakenly or intentionally for testing purposes, patients would not observed any improvement and have not hesitated to express the lack of improvement; i.e., the patient did not show psychological bias toward this procedure.  Correctly relocating the stimulation at noci-points enabled prompt relief/improvement. 


All treatments were done within one to several hours cumulatively, spreading over one to several sessions.  The gap between sessions has minor impact on recovery, positive or negative, for a healthy person.   That is, patients technically can complete all sessions consecutively in a few days.

Patients usually experienced immediate improvement/cure when correct Nocipoints were stimulated.  This contrasts with months if not years of standard pain/injury treatments.   

In sum, the procedure cures pain persistently and permanently.  More importantly, it heals injured muscles and restores functions and full range of motion.  It is quick, repeatable and the same results are observed in nearly all cases

APPENDIX:   A back pain case (with patient’s permission):

The 59 year old patient injured his lower back a week before the treatment while picking up a heavy box.   He had lower back pain and had to roll off the bed every day and wore waist support all days to avoid pain.  Being a medical informatics professor, this patient was skeptical of the procedure.

Before the treatment:  (First photo shows the maximum angle he could bend without incurring the sharp pain)


After a 25-minute treatment:  Full range of motion recovered.  No pain since.